Background:  Transgelin is a homolog of transgelin and is also expressed in smooth muscle cells and by peritoneal B-1 cells. Unlike the other two transgelin proteins, transgelin-3 (also designated TAGLN2, NP22 (neuronal protein 22) or NP25) is predominantly expressed in brain. Transgelin-3 contains a putative Actin-binding domain, two EF-hand motifs, two potential phosphorylation sites and a calponin-homology (CH) domain. Transgelin-3 shares homology with transgelin and Calponin, two cytoskeleton-interacting proteins. Belonging to the calponin family, transgelin-3 colocalizes with Actin and Tubulin, suggesting a possible role for transgelin-3 in neuronal plasticity or as a signaling protein. Due to a varied expression pattern, transgelin-3 may play different roles in the developing and adult brain. Expression of transgelin-3 is upregulated in regions of the human alcoholic brain.

Description: Rabbit polyclonal to Transgelin 3

Immunogen: KLH conjugated synthetic peptide derived from Transgelin 3

Specificity:  ·Reacts with Human, Mouse, Pig, Dog and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 22 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.