Background:   Netrin proteins are a family of laminin-related secreted proteins that provide guidance signals for axonal growth and cell migration during development. Netrin signaling is dependent on the concentration of calcium outside the cell and the level of PKA activity.  n axonal cells, a reduction in PKA activity converts the responsiveness of the axons to the netrin proteins as the cells are repelled, rather than attracted, by the netrin gradient. Netrin-5, also known as NT N5 or netrin-1-like protein, is a 489 amino acid secreted protein that exists as 2 alternatively spliced isoforms. Containing three laminin EGF-like domains, and one NTR domain, netrin-5 is encoded by a gene that maps to human chromosome 19q 13.33. Chromosome 19 consists of over 63 million bases, houses approx imately  1,400 genes and is recognized for having the greatest gene density of the human chromosomes.  t is the genetic home for a number of immunoglobulin ( g) superfamily members, including the killer cell and leukocyte   g-like receptors, a number of    CAMs, the CEACAM and PSG families, and Fc receptors (FcRs).

Description: Rabbit polyclonal to Netrin 5

Immunogen: KLH conjugated synthetic peptide derived from Netrin 5

Specificity:  ·Reacts with Human, Mouse and Rat.

.·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 53 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.