Background:   ACSF4 (aminoadipate-semialdehyde dehydrogenase), also known as AASDH, U26, LYS2, NRPS998, NRPS1098 or acyl-CoA synthetase family member 4, is a 1,098 amino acid protein belonging to the ATP-dependent AMP-binding enzyme family. Encoded by a gene that maps to human chromosome 4q12, ACSF4 is ubiquitously expressed in adult tissues and exists as five alternatively spliced isoforms. ACSF4 is homologous to AASDHPPT, a yeast enzyme necessary for lysine biosynthesis in lower eukaryotes. ACSF4 contains one acylcarrier domain and participates in ATP binding, ligase activity, acid-thiol ligase activity, acyl carrier activity and cofactor and nucleotide binding. ACSF4 catalyzes the initial reaction in fatty acid metabolism by forming a thioester with CoA. Conserved motifs in ACSF4 may engage in functions other than fatty acid activation.

Description: Rabbit polyclonal to ACSF4

Immunogen: KLH conjugated synthetic peptide derived from ACSF4

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 123 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.