Background:  The Tenascin family of extracellular matrix proteins includes Tenascin (also designated cytotactin or Tenascin-C), Tenascin-R (also designated restrictin or janusin), Tenascin-X, and Tenascin-N (also designated TNN, TN-W or Tenascin-W). Tenascin proteins function as substrate-adhesion molecules (SAMs) and are involved in regulating numerous developmental processes, such as morphogenetic cell migration and organogenesis. The Tenascin family proteins arise from various splicing events in the region coding for fibronectin (FN) III repeats. Tenascin-C and Tenascin-X are expressed in several tissues during embryogenesis, and in adult tissues undergoing active remodeling such as healing wounds and tumors. Tenascin-R (TN-R) is expressed on the surface of neurons and glial cells and Tenascin-N, although evident during development, is predominantly expressed by neurons in the adult central nervous system. Tenascin-N may play a role in neurite outgrowth and migration functioning as a repulsive molecule in the hippocampus.

Description: Rabbit polyclonal to Tenascin N

Immunogen: KLH conjugated synthetic peptide derived from Tenascin N

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 144 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.