Background:  Dyneins are multi-subunit, high molecular weight ATPases that interact with microtubules to generate force by converting the chemical energy of ATP into the mechanical energy of movement. Cytoplasmic or axonemal dynein heavy, intermediate, light and light-intermediate chains are all components of minus end-directed motors. Dynein complexes transport cellular cargos toward the central region of the cell. Containing one to three non-identical heavy chains, axonemal dynein motors cause a sliding of microtubules in the axonemes of cilia and flagella in a mechanism necessary for cilia movement and cell propulsion. DNAH8 (dynein, axonemal, heavy chain 8), also known as hdhc9 or ATPase, is a 4,490 amino acid member of the dynein heavy chain protein family. DNAH8 exists as four isoforms produced by alternative splicing events. DNAH8 is a force-generating protein of respiratory cilia and is thought to be involved in sperm motility.

Description: Rabbit polyclonal to DNAH8

Immunogen: KLH conjugated synthetic peptide derived from DNAH8

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 510 kDa;

·Immunohistochemistry (Frozen/paraffin tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

· ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.