Background:  Gap junctions are formed by a hexameric group of proteins called connexins for the transport of low molecular weight proteins. Connexins are present in all metazoan organisms, where they serve diverse functions, ranging from control of cell growth and differentiation to electric conduction in excitable tissues. Several mammalian cells with malignant phenotypes exhibit decreased connexin expression and gap junction communication. Connexin 47 is primarily expressed in the oligodendrocytes of highly myelinated CNS tissues and in a few calcium-binding protein S-100 b subunit-positive cells, but not in neurons or peripheral sciatic nerve. Connexin 47 is co-localized in many gap junction plaques on oligodendrocyte somata, particularly in gray matter.

Description: Rabbit polyclonal to Connexin 47

Immunogen: KLH conjugated synthetic peptide derived from Connexin 47

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 47 kDa;

·Immunohistochemistry (Frozen/paraffin tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.