Background:  ROM1 is a 351 amino acid integral membrane protein found in the photoreceptor disk rim of the eye. Belonging to the PRPH2/ROM1 family, ROM1 exists as a homodimer but can also form heterodimers with retinal degeneration slow (RDS). ROM1 is essential for disk morphogenesis and may also function as an adhesion molecule involved in the stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. Certain defects in the gene encoding ROM1 have been associated with retinitis pigmentosa, a group of genetic eye conditions characterized by the progressive loss of photoreceptor cells that may potentially lead to blindness.

Description: Rabbit polyclonal to ROM1

Immunogen: KLH conjugated synthetic peptide derived from ROM1

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 37 kDa;

·Immunohistochemistry (Frozen/paraffin tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.